15 Apr 2025
Take a look at our new paper where we used PET and MR imaging on human stem cell-derived dopamine grafts in rat models of Parkinson's Disease.
Members of the BRG were involved in this exciting project, resulting in a paper in Neurobiology of Disease, found here: https://www.sciencedirect.com/science/article/pii/S0969996125001263?via%3Dihub
This project used state-of-the-art positron emission tomography (PET) and MR imaging assays to investigate the 6-OHDA medial forebrain bundle lesioned rat model of Parkinson's Disease, which had either been transplanted with hfVM or hESC-derived cells. The aims of the project were twofold: to determine whether graft detection using [18F]Fluorodopa or [18F]Fallypride imaging correlates robustly with behavioural recovery and to explore whether diffusion-weighted MR imaging (DWI) can detect graft-induced cytoarchitectural changes in the host brain.